The Use of Transcranial Focused Ultrasound for the Treatment of Neurodegenerative Dementias

– CDR stage of at least 0.5 (mild cognitive impairment)

– At least one pathognomic imaging biomarker of a neurodegenerative process.

Exclusion Criteria:

– Cognitive decline clearly related to an acute illness

– Subjects unable to give informed consent

– Subjects with scalp rash or open wounds on the scalp (for example from treatment of
squamous cell cancer)

– Advanced terminal illness

– Advanced kidney, pulmonary, cardiac or liver failure

– Subjects who would not be able to lay down without excessive movement in a calm
environment sufficiently long enough to be able to achieve sleep

– Subjects with major depressive disorder

– Subjects with vascular causes of dementia