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Mindfulness Meditation and Insomnia in Alzheimer Disease Caregivers: Inflammatory and Biological Aging Mechanisms


Brief Summary:

Treatment of insomnia in caregivers is needed given that 60% of Alzheimer disease caregivers
report sleep complaints, and insomnia may add to the burden of AD caregiving and contribute
to morbidity and mortality risk. This is the first intervention trial in AD caregivers to
target insomnia and also evaluate two mechanisms of chronic disease risk, inflammation and
cellular aging


Inclusion Criteria:

– Alzheimer or other dementia caregivers

– Older than 45 years of age

– Self-identified as the principal person taking care of the patient with Alzheimer or
other dementia

– Diagnostic and Statistical Manual Criteria – 5 for Insomnia

Exclusion Criteria:

– Psychiatric disorders including current major depressive disorder or other current
DSM-5 psychiatric disorder (e.g. substance dependence) with the exception of anxiety

– Psychotic symptoms;

– Acute suicidal or violent behavior or history of suicide attempt within the last year

– Other sleep disorders including current or lifetime history of sleep apnea, nocturnal
myoclonus, phase-shift disorder as identified by SCID-5 and Duke Structured Interview
for Sleep Disorders (DSISD)

– Medical conditions such as acute or uncontrolled medical illness (e.g., major surgery,
metastatic cancer, Class III heart failure, inflammatory disorder)

– Chronic infections

– Obesity with body mass index (BMI) >35

– Use of hormone containing medications including steroids or immune modifying drugs

– Daily use of analgesics such as opioids;

– Daily us of sedative hypnotic medications

– Cognitive impairment as evidenced by DSM-5 interview and/or Mini-Mental Status Exam
(MMSE < 26) - Actively practicing a mind body intervention.


  • Cousins Center for Psychoneuroimmunology, UCLA Neuropsychiatric Institute, Los Angeles, California, United States, 90095
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