Lifestyle Intervention for Early Alzheimer’s Disease

– Current diagnosis of mild dementia or mild cognitive impairment due to Alzheimer’s
disease/process, with MoCA score above 17 (i.e., 18 or higher)

– Willingness and ability to participate in all aspects of the intervention

– Availability of spouse or caregiver who can provide collateral information and assist
with study adherence

– PET scans and/or C2N testing will be performed at baseline if there is any doubt about
the clinical diagnosis of Alzheimer’s disease

Exclusion Criteria:

– severe dementia

– physical disability that precludes regular exercise

– clear evidence for other causes of neurodegeneration or dementia, e.g., severe
cerebrovascular disease, Parkinson’s disease

– significant ongoing psychiatric or substance abuse problems