Lifestyle Enriching Activities for Research in Neuroscience Intervention Trial: LEARNit Study
Sponsor:
Brief Summary:
exercise and healthy living on brain health. The investigators will compare 2 types of
interventions, moderate aerobic walking vs. healthy living education, over 6 months to
evaluate changes in brain health, cognition, and physical function in older adults with
cognitive concerns.
Criteria
1. Male or female
2. English-speaking
3. 60-80 years old
4. Exhibits sedentary behavior
5. Subjective or objective cognitive impairment
6. Mini-Mental State Exam score > 26
7. Perform at least 1 standard deviations below normative values on cognitive tests
8. Absence of dementia
9. Modified Hachinski score < 4 10. Ability to complete both MRI and PET scans 11. Physically capable of completing health programs Exclusion Criteria: 1. Baseline dementia 2. History of a neurological disorder 3. Current psychiatric illness 4. Head trauma with a loss of consciousness > 10 minutes
5. Severe sensory deficits
6. Substance abuse
7. Depression
8. Inability to perform intervention (e.g., inability to walk without assistance)
9. Contraindications to MRI scan (e.g., pacemaker)
Locations
- University of Southern California, Los Angeles, California, United States, 90032
