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Lifestyle Enriching Activities for Research in Neuroscience Intervention Trial: LEARNit Study


Brief Summary:

The purpose of this study is to examine the effects of modifiable lifestyle factors including
exercise and healthy living on brain health. The investigators will compare 2 types of
interventions, moderate aerobic walking vs. healthy living education, over 6 months to
evaluate changes in brain health, cognition, and physical function in older adults with
cognitive concerns.


Inclusion Criteria:

1. Male or female

2. English-speaking

3. 60-80 years old

4. Exhibits sedentary behavior

5. Subjective or objective cognitive impairment

6. Mini-Mental State Exam score > 26

7. Perform at least 1 standard deviations below normative values on cognitive tests

8. Absence of dementia

9. Modified Hachinski score < 4 10. Ability to complete both MRI and PET scans 11. Physically capable of completing health programs Exclusion Criteria: 1. Baseline dementia 2. History of a neurological disorder 3. Current psychiatric illness 4. Head trauma with a loss of consciousness > 10 minutes

5. Severe sensory deficits

6. Substance abuse

7. Depression

8. Inability to perform intervention (e.g., inability to walk without assistance)

9. Contraindications to MRI scan (e.g., pacemaker)


  • University of Southern California, Los Angeles, California, United States, 90032
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