Exercise Targeting Cognitive Impairment in Parkinson’s Disease

– willing and able to provide informed consent

– confirmed diagnosis of idiopathic PD based on the United Kingdom Brain Bank criteria

– Mild cognitive impairment (Level II criteria Movement Disorder Task Force)

– medically eligible for MRI imaging

– able to provide a written medical clearance from their primary physician to
participate in exercise

– stable PD medications for 3 months

Exclusion Criteria:

– a Hoehn & Yahr staging greater than 2.5 at screening

– severe cardiac disease (New York Heart Association classification IIIV)

– history of an abnormal stress test

– clinically significant medical or psychiatric illness

– electrically, magnetically, or mechanically activated implant (such as cardiac
pacemakers or intracerebral vascular clip)

– metal in any part of the body including metal injury to the eye

– past history of brain lesions (such as stroke)

– seizures or unexplained spells of loss of consciousness

– family history of epilepsy

– physical therapy within 6 months of the study

– symptomatic orthostatic hypotension at the screening visit

– orthopedic and other movement-influencing diseases such as arthritis or total hip
joint replacement

– requirement for central nervous system active therapies (e.g. hypnotics,
antidepressants, anxiolytics)

– moderate or severe depression or apathy using the Geriatric depression scale and
Apathy scale

– taking anticholinesterase inhibitors

– taking anticholinergic medication

– PD dementia

– Colorblindness