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Computerized Cognitive Training for Patients With Cognitive Deficits Due to Multiple Sclerosis: a Pilot Study


Brief Summary:

WHO: 40 participants with a confirmed diagnosis of Multiple Sclerosis (MS) able to engage in
moderate physical activity.

WHY: The purpose of this study is to evaluate two computerized brain training tools, which
include light physical activity, to see if they can help improve cognitive functions, such as
memory and attention, for patients with MS.

WHAT: Complete a set of tests (physical and cognitive) at baseline, wear a Fitbit Flex device
at home for the duration of the study, 3 supervised sessions for 4 weeks at UCSF, one visit
for physical and cognitive tests at one week after the final supervised session, and one
final visit 6 months after the final supervised session.

WHERE: 20 participants at the UCSF Weill Institute for Neurosciences (675 Nelson Rising Lane,
San Francisco, CA); 20 participants at Lausanne University Hospital (Rue du Bugnon 46, 1005
Lausanne, Switzerland)


Inclusion Criteria:

– Age between 18 and 60 years

– Presence of subjective cognitive complain from patient

– Objective general cognitive impairment: paper-and-pencil Symbol Digit Modalities Test
(SDMT) z-score < -0.5 at screening Exclusion Criteria: - Falls in the past 12 weeks as evaluated in the enrollment interview [Hopkins Falls Grading Scale (Grade >1)]

– Strong risk of falling, assessed using the miniBEST (score< 16) - Psychiatric co-morbidity or anti-depressive or anxiolytic medication that has been changed over the 6 months preceding consideration for study enrollment - Colorblindness - Presence of clinically and/or radiologically confirmed relapses or disease progression in the past 12 weeks. - Visual, mental, motor or brainstem Functional Systems Score (FSS) on the Expanded Disability Status Scale (EDSS) superior to 2.


  • Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, United States, 94158
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