Amyotrophic Lateral Sclerosis – CALIFORNIA NEUROLOGY SOCIETY

An Extension Study to Assess the Long-Term Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB067 Administered to Previously Treated Adults With Amyotrophic Lateral Sclerosis Caused by Superoxide Dismutase 1 Mutation

Sponsor:BiogenBrief Summary: The primary objective of the study is to evaluate the long-term safety and tolerability of BIIB067 in participants…

A Phase 2a Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic (PD) Study of Intravenous ANX005 in Subjects With Amyotrophic Lateral Sclerosis (ALS)

Sponsor:Annexon, Inc.Brief Summary: The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of Intravenous ANX005…

A Phase 3, Randomized Double-Blind, Placebo-Controlled Multicenter Study to Evaluate Efficacy and Safety of Repeated Administration of NurOwn® (Autologous Mesenchymal Stem Cells Secreting Neurotrophic Factors) in Participants With ALS

Sponsor:Brainstorm-Cell TherapeuticsBrief Summary: This study will evaluate the safety and efficacy of repeated administration of NurOwn® (MSC-NTF cells) therapy, which…

Clinical Procedures to Support Research in ALS (CAPTURE-ALS)

Sponsor:University of MiamiBrief Summary: The purpose of the Clinical Procedures To Support Research (CAPTURE) study is to utilize information collected…

A Phase 3, Randomised, Placebo-Controlled Trial of Arimoclomol in Amyotropic Lateral Sclerosis

Sponsor:OrphazymeBrief Summary: A multicenter, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of arimoclomol in amyotropic…

A Phase 1 Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 Administered Intrathecally to Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis

Sponsor:BiogenBrief Summary: The primary objective of this study is to evaluate the safety and tolerability of BIIB078 in adults with…

Open Label, Non-randomized Extension Trial to Assess Long Term Safety and Efficacy of Arimoclomol in Subjects With Amyotropic Lateral Sclerosis Who Have Completed the ORARIALS-01 Trial

Sponsor:OrphazymeBrief Summary: A multicenter, non-randomized, open label trial, to assess long term safety and efficacy of Arimoclomol in subjects with…

A Phase 1, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB100 Administered Orally to Adult Participants With Amyotrophic Lateral Sclerosis

Sponsor:BiogenBrief Summary: The primary objective of this study is to evaluate the safety, tolerability of single-ascending doses of BIIB100 in…

A Pilot Study to Assess Transmembrane Electromyography (TM-EMG) for the Assessment of Neuromuscular Function in the Oropharynx

Sponsor:Powell Mansfield Inc.Brief Summary: This is a pilot study to examine the diagnostic utility of a novel transmembrane surface sensor,…

A Phase 2b/3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, 12 Month Clinical Trial to Evaluate the Efficacy and Safety of MN-166 (Ibudilast) Followed by Open-Label Extension Phase in Subjects With Amyotrophic Lateral Sclerosis

Sponsor:MediciNovaBrief Summary: A Phase 2b/3 multicenter, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy, safety and tolerability of…