Genomic Translation for Amyotrophic Lateral Sclerosis Care
Sponsor:Columbia UniversityBrief Summary: The purpose of this study is to look for abnormal genes and gene expression profiles that help…
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HEALEY ALS Platform Trial
Sponsor:Merit E. Cudkowicz, MDBrief Summary: The HEALEY ALS Platform Trial is a perpetual multi-center, multi-regimen clinical trial evaluating the safety…
Fluid Biomarkers With Deep Phenotyping in Patients With ALS
Sponsor:Barrow Neurological InstituteBrief Summary: This study aims to establish a biorepository and phenotyping database to investigate longitudinal changes in ALS…
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
Sponsor:Mayo ClinicBrief Summary: ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through…
An Extension Study to Assess the Long-Term Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB067 Administered to Previously Treated Adults With Amyotrophic Lateral Sclerosis Caused by Superoxide Dismutase 1 Mutation
Sponsor:BiogenBrief Summary: The primary objective of the study is to evaluate the long-term safety and tolerability of BIIB067 in participants…
A Phase 2a Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic (PD) Study of Intravenous ANX005 in Subjects With Amyotrophic Lateral Sclerosis (ALS)
Sponsor:Annexon, Inc.Brief Summary: The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of Intravenous ANX005…
A Phase 3, Randomized Double-Blind, Placebo-Controlled Multicenter Study to Evaluate Efficacy and Safety of Repeated Administration of NurOwn® (Autologous Mesenchymal Stem Cells Secreting Neurotrophic Factors) in Participants With ALS
Sponsor:Brainstorm-Cell TherapeuticsBrief Summary: This study will evaluate the safety and efficacy of repeated administration of NurOwn® (MSC-NTF cells) therapy, which…
Clinical Procedures to Support Research in ALS (CAPTURE-ALS)
Sponsor:University of MiamiBrief Summary: The purpose of the Clinical Procedures To Support Research (CAPTURE) study is to utilize information collected…
A Phase 3, Randomised, Placebo-Controlled Trial of Arimoclomol in Amyotropic Lateral Sclerosis
Sponsor:OrphazymeBrief Summary: A multicenter, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of arimoclomol in amyotropic…
A Phase 1 Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 Administered Intrathecally to Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis
Sponsor:BiogenBrief Summary: The primary objective of this study is to evaluate the safety and tolerability of BIIB078 in adults with…
