Clinical Procedures to Support Research in ALS (CAPTURE-ALS)
Sponsor:University of MiamiBrief Summary: The purpose of the Clinical Procedures To Support Research (CAPTURE) study is to utilize information collected…
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A Phase 3, Randomised, Placebo-Controlled Trial of Arimoclomol in Amyotropic Lateral Sclerosis
Sponsor:OrphazymeBrief Summary: A multicenter, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of arimoclomol in amyotropic…
A Phase 1 Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 Administered Intrathecally to Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis
Sponsor:BiogenBrief Summary: The primary objective of this study is to evaluate the safety and tolerability of BIIB078 in adults with…
Open Label, Non-randomized Extension Trial to Assess Long Term Safety and Efficacy of Arimoclomol in Subjects With Amyotropic Lateral Sclerosis Who Have Completed the ORARIALS-01 Trial
Sponsor:OrphazymeBrief Summary: A multicenter, non-randomized, open label trial, to assess long term safety and efficacy of Arimoclomol in subjects with…
A Phase 1, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB100 Administered Orally to Adult Participants With Amyotrophic Lateral Sclerosis
Sponsor:BiogenBrief Summary: The primary objective of this study is to evaluate the safety, tolerability of single-ascending doses of BIIB100 in…
A Pilot Study to Assess Transmembrane Electromyography (TM-EMG) for the Assessment of Neuromuscular Function in the Oropharynx
Sponsor:Powell Mansfield Inc.Brief Summary: This is a pilot study to examine the diagnostic utility of a novel transmembrane surface sensor,…
A Phase 2b/3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, 12 Month Clinical Trial to Evaluate the Efficacy and Safety of MN-166 (Ibudilast) Followed by Open-Label Extension Phase in Subjects With Amyotrophic Lateral Sclerosis
Sponsor:MediciNovaBrief Summary: A Phase 2b/3 multicenter, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy, safety and tolerability of…
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Sponsor:Leigh R. Hochberg, MD, PhD.Brief Summary: The purpose of this study is to obtain preliminary device safety information and demonstrate…
Oxidative Markers and Efficacy in Amyotrophic Lateral Sclerosis (ALS) Phenotypes Treated With Edaravone
Sponsor:Loma Linda UniversityBrief Summary: This study is being conducted to help the investigators better understand how the new FDA approved…
Multi-centered Double Blind, Placebo Controlled Study Evaluating the Safety and Efficacy of Memantine at 20 mg BID in Patients With ALS
Sponsor:University of Kansas Medical CenterBrief Summary: The purpose of this study is to determine if memantine at 20 mg BID…
