BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Sponsor:Leigh R. Hochberg, MD, PhD.Brief Summary: The purpose of this study is to obtain preliminary device safety information and demonstrate…
[searchandfilter fields="search,category" post_types="post"]
Oxidative Markers and Efficacy in Amyotrophic Lateral Sclerosis (ALS) Phenotypes Treated With Edaravone
Sponsor:Loma Linda UniversityBrief Summary: This study is being conducted to help the investigators better understand how the new FDA approved…
Multi-centered Double Blind, Placebo Controlled Study Evaluating the Safety and Efficacy of Memantine at 20 mg BID in Patients With ALS
Sponsor:University of Kansas Medical CenterBrief Summary: The purpose of this study is to determine if memantine at 20 mg BID…
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Amyotrophic Lateral Sclerosis
Sponsor:ProgenaBiomeBrief Summary: This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding…
Phenotype, Genotype & Biomarkers in ALS and Related Disorders
Sponsor:University of MiamiBrief Summary: The goals of this study are: (1) to better understand the relationship between the phenotype and…
A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Parallel Group, Multicenter Study With an Open-Label Extension to Evaluate the Efficacy and Safety of Ravulizumab in Patients With Amyotrophic Lateral Sclerosis (ALS)
Sponsor:Alexion PharmaceuticalsBrief Summary: The purpose of the study is to assess the efficacy and safety of ravulizumab for the treatment…
Rare Diseases Clinical Research Network Advancing Research and Treatment for Frontotemporal Lobar Degeneration [ARTFL]: Research Projects 1 & 2
Sponsor:University of California, San FranciscoBrief Summary: Frontotemporal Lobar Degeneration (FTLD) is the neuropathological term for a collection of rare neurodegenerative…
Radicava® (Edaravone) Findings in Biomarkers From ALS (REFINE-ALS)
Sponsor:Mitsubishi Tanabe Pharma America Inc.Brief Summary: REFINE-ALS is a prospective, observational, longitudinal, multicenter study designed to identify biomarkers to serve…
A Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB067 Administered to Adult Subjects With Amyotrophic Lateral Sclerosis and Confirmed Superoxide Dismutase 1 Mutation
Sponsor:BiogenBrief Summary: The primary objective of Parts A and B of this study is to evaluate the safety, tolerability, and…
An Extension Study to Assess the Long-Term Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB078 Administered to Previously Treated Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis
Sponsor:BiogenBrief Summary: The primary objective is to evaluate the long-term safety and tolerability of BIIB078 in participants with chromosome 9…
