ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

Familial FTLD (f-FTLD) participants (either is acceptable):

– members of families in whom at least one member has a known disease-associated
mutation in one of the major genes that cause f-FTLD: MAPT, GRN, C9orf72 (or other
rare genes)

– an autosomal dominant family history of a FTLD syndrome (without a known gene)
verified by medical record review or well-documented family history including family
members with a medical history consistent with FTLD or a related disorder.

Sporadic FTLD (s-FTLD) participants:

Sporadic participants should be symptomatic with no known family history nor a genetic
mutation indicating f-FTLD. All sporadic participants must have an FTLD syndrome as a
referring diagnosis; those determined by ALLFTD clinicians to have non-FTLD diagnoses will
be excluded from longitudinal visits, but their baseline visit will be included in
comparative datasets. For inclusion in the longitudinal follow-up, participants should meet
research criteria for one of the following FTLD syndromes:

– Progressive Supranuclear Palsy (PSP)

– Semantic variant Primary Progressive Aphasia (svPPA)

– Nonfluent variant Primary Progressive Aphasia (nfvPPA)

– Corticobasal Degeneration (CBD)/Corticobasal Syndrome (CBS)

– Behavioral variant Frontotemporal dementia (bvFTD)

– Frontotemporal Dementia with Amyotrophic Lateral Sclerosis (FTD/ALS)

Biofluid-Focused Arm Inclusion Criteria

Participants enrolled in the biofluid arm may be either f-FTLD or s-FTLD. All general
inclusion criteria apply. Participants should meet research criteria (as specified above)
for any FTLD syndrome or meet familial FTLD inclusion criteria. Because the biofluid arm
participants do not undergo the same detailed clinical and functional assessments required
for the longitudinal arm, participants may be included regardless of primary language, as
long as an appropriately translated consent is available.

Exclusion Criteria:

– Known presence of a structural brain lesion (e.g. tumor, cortical infarct) that could
reasonably explain symptoms in a symptomatic participant.

– Known presence of an Alzheimer’s disease causing mutation in PSEN1, PSEN2 or APP; or
biomarker evidence for Alzheimer’s disease as a cause of the clinical syndrome.

– A previous history of Korsakoff encephalopathy, severe alcohol dependence (within 5
years of onset of dementia), frequent alcohol or other substance intoxication, or
other neurological disorder.

– Evidence through history or laboratory testing of uncorrected B12 deficiency (B12 < 95% of local laboratory's normal value), unregulated hypothyroidism (TSH >150% of
normal), HIV positive, renal failure (creatinine > 2), liver failure (ALT or AST > two
times normal), respiratory failure that requires supplemental oxygen, large confluent
white matter lesions, significant systemic medical illnesses such as deteriorating
cardiovascular disease.

– Current medication likely to affect CNS functions in the opinion of the site PI.

– In the site investigator’s opinion, the participant cannot complete sufficient key
study procedures. The participant may be enrolled into the biofluid-focused arm if
they can tolerate a blood draw and short clinical exam, but must be able to complete
at least 75% of study procedures for enrollment into the longitudinal arm.