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Antigen Presentation and Lymphocyte Response in Parkinson’s Disease


Brief Summary:

The way the immune system responds to certain PD-related proteins in PD donors compared to
the way it responds in persons without or fewer PD related proteins is not well studied and
this study aims to analyze the autoimmune response in each group. The study involves a one
time visit involving brief questionnaires and a blood draw of 30 mL (approximately 2
tablespoons) to be collected.


Inclusion Criteria:

– Moderate to advanced PD with classic motor features, and must demonstrate two of the
following three: rest tremor, rigidity, or bradykinesia

– Dopaminergic medication benefit (self-reported improvement)

– Age at recruitment: 50 – 90 years

– Age at diagnosis > 47

– PD duration > 3 years

– Willingness to have genotyping and genetic studies as part of laboratory research

Exclusion Criteria:

– Atypical parkinsonism or other neurological disorders

– Recent history of cancer (past 3 years)

– Autoimmune disease (except thyroid disease)

– On chronic immune-modulatory therapy (e.g. SIT (specific immunotherapy), anti-IgE)

– Inability to provide informed consent


  • University of California San Diego School of Medicine, La Jolla, California, United States, 92037
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