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An Open-label Study to Investigate the Effectiveness of a LifeSeasons NeuroQ Supplement in Addition to Four Bredesen Recommended Lifestyle Changes to Improve Cognitive Function in Healthy Adults Who Have One or More Risk Factors for Cognitive Decline


Brief Summary:

The objective of this study is to evaluate the efficacy of a NeuroQ supplement designed by
Dr. Bredesen to complement his Lifestyle modification protocol. Eligible participants will be
expected to consume the NeuroQ supplement and are recommended to make lifestyle changes based
on Dr. Bredesen’s protocol. Forty participants are expected to enroll into the study,
completing study assessments at check in visits days 30 and 60, and at the end of study visit
on day 90. A brief follow up phone call will be conducted approximately 30 days after study
completion to ask participants if they have continued using the lifestyle changes and if they
have purchased and continued to consume the NeuroQ supplement.


Inclusion Criteria:

1. Males and females 45 years of age or older with one or more of the following risk
factors for cognitive decline:

– Self-reported genetic risk factor of Alzheimer’s Disease or dementia as confirmed
by Apolipoprotein 4 genetic testing

– Self-reported family history of Alzheimer’s Disease or dementia in a first-degree

– Self-reported lifestyle risk factor: sedentary lifestyle; poor dietary habits
(e.g. insufficient consumption of fruits and vegetables for necessary nutrients);
poor social support network (e.g. majority of evenings and weekends are spent in
isolation); poor stress management skills (e.g. binge eating habits or performing
harmful activities during periods of stress); poor sleep habits; metabolic

– Exception: Individuals 60 years of age or older may be enrolled without any of
the above risk factors.

2. BMI between 18.5 and 32.5 kg/m2

3. Female participants are not of child-bearing potential, defined as females who have
undergone a sterilization procedure (e.g. hysterectomy, bilateral oophorectomy,
bilateral tubal ligation, complete endometrial ablation) or have been post-menopausal
(natural or surgically) for at least 1 year prior to screening


Females of child-bearing potential must have a negative baseline urine pregnancy test and
agree to use a medically approved method of birth control for the duration of the study.
All hormonal birth control must have been in use for a minimum of three months. Acceptable
methods of birth control include:

– Hormonal contraceptives including oral contraceptives, hormone birth control patch
(Ortho Evra), vaginal contraceptive ring (NuvaRing), injectable contraceptives
(Depo-Provera, Lunelle), or hormone implant (Norplant System)

– Double-barrier method

– Intrauterine devices

– Non-heterosexual lifestyle or agrees to use contraception if planning on changing to
heterosexual partner(s)

– Vasectomy of partner at least 6 months prior to screening 4. Self-reported as
non-smoker or user of any nicotine-containing products 5. Absence of dementia or other
significant cognitive impairment as assessed by Mini Mental State Exam-2 Standard
Version (MMSE-2) score ≥24 6. Participants who test between the 24-75th percentile in
the in one or more domains in the NCI 7. Low frequency of depressed mood as assessed
by PHQ-9 score of 4 or less 8. Agree to avoid caffeine consumption 24 hours prior to
in-clinic visits 9. Agree to avoid alcohol consumption 24 hours prior to in-clinic
visits 10. Healthy as determined by medical history and laboratory results as assessed
by QI

Exclusion Criteria:

1. Women who are pregnant, breast feeding, or planning to become pregnant during the

2. Allergy, sensitivity, or intolerance to the investigational product’s (IP) active or
inactive ingredients

3. Self-reported confirmation of neuropsychological condition and/or cognitive impairment
that, in the QI’s opinion, could interfere with study participation. For e.g.:

• Schizophrenia, bipolar disorder, post-traumatic stress disorder, brain injury,
neurodegenerative disease, infections, insomnia

4. Participants with vitamin deficiencies affecting cognition:

– Magnesium

– Cobalamin (Vitamin B12)

– Folate below the normal clinical ranges, as assessed by the QI

5. Participants who test below the 24th percentile or above the 75th percentile in all
domains in the NCI.

6. Current use of prescribed medications listed in Section 8.3.1.

7. Current use of over-the-counter medications, supplements, foods and/or drinks listed
as concomitant medications.

8. Unstable metabolic disease or chronic diseases as assessed by the QI

9. Unstable hypertension. Treatment on a stable dose of medication for at least 3 months
will be considered by the QI

10. Type II diabetes. Treatment on a stable dose of medication may be considered by the QI
on a case by case basis

11. Significant cardiovascular event in the past 6 months. Participants with no
significant cardiovascular event on stable medication may be included after assessment
by the QI on a case by case basis

12. Major surgery in the past 3 months or individuals who have planned surgery during the
course of the trial. Participants with minor surgery will be considered on a
case-by-case basis by the QI

13. Cancer, except skin cancers completely excised with no chemotherapy or radiation with
a follow up that is negative. Volunteers with cancer in full remission for more than
five years after diagnosis are acceptable

14. Individuals who are immune-compromised

15. Verbal confirmation of a HIV-, Hepatitis B- and/or C-positive diagnosis

16. History of or current diagnosis with kidney and/or liver diseases as assessed by the
QI on a case-by-case basis, with the exception of history of kidney stones symptom
free for 6 months

17. Verbal confirmation of current or pre-existing thyroid condition. Treatment on a
stable dose of medication for at least 3 months will be considered by the QI

18. Current or history of any significant diseases of the gastrointestinal tract

19. Verbal confirmation of blood/bleeding disorders

20. Self-reported chronic use of cannabinoid products or currently taking medical
cannabinoid products containing >0.3% tetrahydrocannabinol

21. Alcohol or drug abuse within the last 12 months

22. High alcohol intake (>2 drinks per day or >10 standard drinks per week)

23. Blood donation 30 days prior to screening, during the study, or a planned donation
within 30-days of the last study visit

24. Participation in other clinical research trials 30 days prior to screening

25. Individuals who are unable to give informed consent

26. Any other active or unstable medical condition, that, in the opinion of the QI, may
adversely affect the participant’s ability to complete the study or its measures or
pose significant risk to the participant


  • Kapoor Medical Center, Studio City, California, United States, 91604
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