– Diagnosed with idiopathic PD.
– Adequate duration of levodopa therapy.
– Disease duration of at least 5 years or more.
– Modified Hoehn & Yahr Staging with at least 2.5 hours or more in the OFF state.
– Candidate for surgical intervention because of disabling motor complications.
– UPDRS Part III (total score) of at least 25 in the OFF state.
– Unequivocal responsiveness to dopaminergic therapy.
– Stable Parkinson’s symptoms and medications for at least 4 weeks prior to screening
– Ability to comprehend and sign the informed consent.
– Normal laboratory values prior to surgery.
– Medically and mentally capable of undergoing and complying with the surgical procedure
and protocol requirements.
– Ability to travel to study visits alone or able to designate a caregiver.
– Subject agrees to defer any neurological surgery, including deep brain stimulation,
until after completing the 12 month study visit (unless recommended by study
– Approved by the Eligibility Review Committee.
– Atypical or secondary parkinsonism, including but not limited to symptoms believed to
be due to trauma, brain tumor, infection, cerebrovascular disease, other neurological
disease, or to drugs, chemicals, or toxins.
– Presence of dementia as defined by a Mattis Dementia Rating Scale – Second Edition
(MDRS-2) score of less than 130 at screening.
– Presence or history of psychosis, with the exception of mild, benign hallucinations
believed in the judgment of the Investigator to be related to Parkinson’s medications.
– Presence of severe depression, as indicated by a BDI-II score greater than 28, or a
history of a major affective disorder within 5 years of screening evaluation.
– Active suicidal ideation or suicide attempt within 5 years of screening evaluation.
– History of substance abuse within 2 years of screening evaluation.
– Brain imaging abnormalities in the striatum or other regions that would substantially
increase risk of surgery.
– Contraindication to MRI and/or gadoteridol.
– Coagulopathy or inability to temporarily stop any anticoagulation or antiplatelet
therapy prior to surgery.
– Prior brain surgery including lesioning procedures, deep brain stimulation, infusion
therapies or any other brain surgery.
– Prior gene transfer.
– History of stroke, poorly controlled or significant cardiovascular disease, diabetes,
or any other acute or chronic medical condition.
– History of malignancy other than treated carcinoma in situ within 3 years of screening
– Clinically apparent or laboratory-detected infection.
– Prior or current treatment with any investigational agent within 2 months of screening
– Inability to comply with the procedures of the protocol, including completion of paper
Parkinson’s disease diaries, frequent and prolonged study visits including off
medication visits, and travel.
– Chronic immunosuppressive therapy, including chronic steroids, immunotherapy,
cytotoxic therapy, and chemotherapy.
– Any serious medical condition or abnormal finding on physical examination or
laboratory investigation that would substantially increase the risks of the study
– Any medical condition that is likely to lead to disability during the course of the
study and interfere with or confound study assessments.
– Pregnant and lactating women.
– Male or female with reproductive capacity who is unwilling to use barrier
contraception for 6 months after surgery.
– Plans to receive any vaccination within 30 days of surgery.
– Any factors, medical or social, which would likely cause the participant to be unable
to follow the study protocol, including geographical inaccessibility.
– Ongoing treatments including neuroleptic medications, apomorphine, or levodopa
infusion therapy (Duopa®).
– Plans to participate in any other therapeutic intervention study within 12 months
- University of California, San Francisco (UCSF), San Francisco, California, United States, 94143