A Phase IIB, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson’s Disease

– Diagnosis of idiopathic PD based on MDS criteria with bradykinesia plus one of the
other cardinal signs of PD (resting tremor, rigidity), without any other known or
suspected cause of parkinsonism

– On symptomatic PD medication for at least 6 months, with stable doses for 3 months
prior to baseline

– A diagnosis of PD for at least 6 months to maximum 3 years at screening

– MDS-UPDRS Part IV score= 0

– Hoehn and Yahr (H&Y) Stage I or II in ON and OFF states

– Dopamine transporter imaging with single photon emission computed tomography
(DaT-SPECT) imaging consistent with dopamine transporter deficit, as assessed by the
central reader

– No anticipated changes in PD medication from baseline throughout the study duration
based on clinical status during screening

– Willingness and ability to use a smartphone application to measure PD-related symptoms
for the duration of the study

– Willingness and ability to wear a smartwatch to measure PD-related motor signs

Exclusion Criteria:

– Medical history indicating a Parkinsonian syndrome other than idiopathic PD

– Diagnosis of PD dementia

– Diagnosis of a significant central nervous system (CNS) disease other than Parkinson’s
disease

– Within the last year, unstable or clinically significant cardiovascular disease

– Uncontrolled hypertension

– Drug and/or alcohol abuse within 12 months prior to screening, in the investigator’s
judgment (Nicotine is allowed, Marijuana use is not allowed)

– Clinically significant abnormalities in laboratory test results at the screening
visit, including hepatic and renal panels, complete blood count, chemistry panel and
urinalysis

– Allergy to any of the components of prasinezumab, a known hypersensitivity, or a
previous IRR following administration of any other monoclonal antibody

– Any contraindications to obtaining a brain magnetic resonance imaging (MRI)

– Any contraindications to DaT-SPECT imaging